Ribociclib Effective in Younger Breast Cancer Patients Too

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  1. Ribociclib Effective in Younger Breast Cancer Patients Too  Medscape
  2. For Breast Cancer Patients, Less Time on Hormonal Meds?  HealthDay
  3. SABCS: I-SPY 3-year pCR results are powerful predictor for breast cancer survival  EurekAlert (press release)
  4. Widespread screening for breast cancer didn’t do much to save women’s lives, study finds  Los Angeles Times
  5. Full coverage

SAN ANTONIO The CDK inhibitor ribociclib Kisqali, Novartis dramatically improves progression free survival PFS when added to endocrine therapy in ovarian suppressed younger patients with hormone receptor positive HR , human epidermal receptor negative HER advanced breast .Cyclin dependent kinase CDK inhibitors have advanced the treatment of metastatic breast cancer by targeting the cell cycle machinery, interrupting intracellular and mitogenic hormone signals that stimulate proliferation of malignant cells. Preclinical evidence demonstrated that derangements of cyclin D, CDK and ."There is a clear unmet need in premenopausal patients with hormone receptor positive, HER negative breast cancer. It s estimated that in this country about of breast cancers are diagnosed in women under the age of , and these younger patients have a different biology, with more aggressive .In premenopausal women with HR positive, HER negative advanced breast cancer, the CDK inhibitor plus endocrine therapy dramatically improves progression free survival compared with endocrine therapy alone. Medscape Medical News. This post was syndicated from Medscape Medical News Headlines..

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